Controlled Studies of Clomiphene Citrate
as Empiric Therapy
| Author (Year) | Clomiphene Dosage Control Drug | Duration (Months) | Subjects | Pregnancy Rates (%) |
| Foss (1973)88 | 100 mg/day Placebo |
3 3 |
108 101 |
17** |
| Paulson (1979)89 | 25 mg/day Cortisone, 10 mg/day |
6 6 |
20 20 |
35 10 |
| Ronnberg (1980)90 | 50 mg/day Placebo |
3 3 |
27 29 |
10 3 |
| Abel (1982)91 | 50 mg/day Vitamin C, 200 mg/day |
9 9 |
98 89 |
17 13 |
| Wang (1983)92 | 25 mg/day 50 mg/day Placebo |
6-9 6-9 6-9 |
11 18 7 |
36 22 0 |
| Micic (1985)93 | 50 mg/day No treatment |
6-9 6-9 |
56 45 |
13 0 |
| Sokol (1988)94 | 25 mg/day Placebo |
12 12 |
23 23 |
9 44 |
| Check (1989)95 | 25 mg/day Placebo |
8 8 |
50 50 |
58 16 |
| WHO (1992)96 | 25 mg/day Placebo |
6 6 |
94 96 |
8 12 |
* these studies did not report improvement in bulk seminal parameters in a consistant manner.
**Overall pregnancy rate for clomiphene and placebo groups combined